Penn Pharma Launches Formulation Service

Penn Pharma, has launched Solusolve, a specialist formulation development service to increase the bioavailability of ‘difficult’ compounds. Solusolve uses several techniques for increasing water-solubility of lipophilic compounds, including salt selection, particle reduction, use of carriers, such as solution formulations and self-emulsifying drug delivery systems, melt extrusion and granulation and functional ‘bioavailability enhancer’ excipients, such as Gelucire and Vitamin E TPGS.

Paul Wituschek, Penn Pharma’s global sales and marketing director, commented, “The majority of medicines being developed for human use are for oral administration.However, an increasing number — in fact almost half — of all new compounds coming through the development pipelines are BCS Class II drugs.This means that they are highly permeable through biological membranes but are poorly water-soluble.And it is this limited water solubility that poses drug absorption problems in the patient’s gastrointestinal tract.The prime objective of our new formulation service is to improve water-solubility to maximize oral bioavailability of these drugs for our clients.”

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